I think you get you 'out of memory' errors because your file has no \n in it but your end of line is \n by default. So perl tries to eat the multi GB line and get the error. A naive try is this: 
perl -pe 'BEGIN { $/ = "RowwoR"; };s/RowwoR/\n/' <infile >outfile

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In reply to Re: search/replace very large file w/o linebreaks by borisz
in thread search/replace very large file w/o linebreaks by Anonymous Monk

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