Build yourself a killer resume.
Put all of your excellent skills and experience at the beginning of it.
Write a cover letter that shows that you know the domain, the job, and the company.
Don't be afraid to tweak each resume you send out to appeal to that particular company.

I don't have a degree either, and this strategy has worked well for me since 1997.

In reply to Re: Climbing the corporate ladder by McMahon
in thread Climbing the corporate ladder by drewbie

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