Please correct me if I am wrong, but is the configuration option not supposed to be -Duselargefiles (instead of -Duselargerfiles as shown in your post)? When checking the configuration on my own build of perl (which does have large file support), I receive the following output: 
rob@robc:~ > /opt/bin/perl -V | grep -i large
    useperlio=undef d_sfio=undef uselargefiles=define usesocks=undef
  Compile-time options: USE_LARGE_FILES

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perl -le "print unpack'N', pack'B32', '00000000000000000000001011100011'"

In reply to Re^3: Problem with Large Files by rob_au
in thread Problem with Large Files by Dru

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