You could use the EFOO constants from the POSIX module and check against $! in a numeric context. 

use POSIX qw( :errno_h );

## Something that fails here 

if( $! == EISDIR ) {
  warn "error was directory\n"
}

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In reply to Re: Testing for read() failures on different platforms by Fletch
in thread Testing for read() failures on different platforms by leriksen

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