I am trying this and it works fine for me, perl version 5.005_03. Is B up to anything else that makes it hang ? Can you run the test code below (with the right path to B) on your system ? 
#!/usr/local/bin/perl -w
#### A ####
use IPC::Open2;
open2( \*READ, \*WRITE, '/home/random/B' );
print WRITE "Hello there.\n";
my $in=<READ>;
print "$0 read: $in\n"

#!/usr/local/bin/perl -w
#### B ####
$input = <STDIN>;
print "echo back: $input";

[download]
Regards,
R.

update

I think the following reply has the answer, set autoflush with $|=1 in B or A may hang while the data from B is hanging around in buffer.

In reply to Re: Pipe problems by Random_Walk
in thread Pipe problems by tran_sonic

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