I doubt that it is a problem with DBI/DBD::mysql, mainly because DBD::mysql is reporting that the server closed the connection. It sounds like somesort of timeout, too large of a packect, commands being sent out of order, or something else that causes the server to go away (segfault is a possibility too).
You might want to enable tracing on the serverside, to see why the connection is going away.
You can try also the DBD::mysql mailing list
In reply to Re^3: DBD::MySQL timeout during query
by tantarbobus
in thread DBD::MySQL timeout during query
by rcraig
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