Here is a random opinion.
In my experience Microsoft Access in multi-user mode has some nasty race conditions. Put it under load and it will randomly lock up and fall over. That would make it significantly less robust than MySQL.
If you value standards compliance, MySQL wins over Access. (eg Should like use a * or % as the wildcard?) Likewise MySQL does not tie you to a specific OS platform.
I have no idea which has a better optimizer. I am certainly unimpressed with the Jet engine. But I've never thrown complex queries at MySQL, so I can't say how it compares.
But on features, I'd suspect that Access wins. If not in features that I care about...
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