Tk requires that you have a correctly configured C compiler. Additionally that compiler will need to be the same one used to compile Perl (probably M$ CL.EXE on Win32) Additionally you need a number of perl header files ie perl.h (which simply may not be present). See A Practical Guide to Compiling C based Modules under ActiveState using Microsoft C++.

The path of least resistance will be to install ActivePerl (either 5.6.x or 5.8.x) from ActiveState and then use ppm to install a binary of Tk which is as simple as typing ppm install Tk at the command prompt. You can install this new Perl separately to the matlab Perl or possibly overwrite it. The file association for .pl and the path determine which version of perl will be run.

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