Ok, here's the entire sub: 
sub find_replace {
    my $filename = shift;
    open (my $infile, "$dir/$filename") or die "Can't open file: $!";
    my $outdata = "";
    while (<$infile>) {
        $outdata .= $_;
        $outdata =~ s{../CLRIS/}{}g;
        $outdata =~ s{../../menu/}{}g;
        $outdata =~ s{../../Images}{Images}g;
        $outdata =~ s{<cfmail}{<!--- <cfmail}g;
        $outdata =~ s{</cfmail>}{</cfmail> --->}g;
    }
    close $infile;
    open (my $outfile, "+>$dir/$filename") or die "Can't open file: $!
+";
    print $outfile "$outdata";
    close $outfile;
}

[download]
The first three replacements work correctly.

P.S. I gave the before/after data in my first post. I'm using ActivePerl 5.8.4.810.

In reply to Re^2: Unexpected results from a regex replacement by yacoubean
in thread Unexpected results from a regex replacement by yacoubean

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