Related to the previous answer: you can make HTML Applications (HTA) with ActiveState PerlScript. An HTML Application is an HTML page which runs in the same security context as an 'exe' file. 


<script language="perlscript">
## perl goes here
</script>

[download]

Again, this is not cross platform and is IE only.

Also see the Perl-Win32-ASP FAQ

In reply to Re: How to write standalone HTML GUI? by dimar
in thread How to write standalone HTML GUI? by chunlou

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