Profiling lookups on one of our table using the existing code gives 670 lookups/second using the (poorly written, IMHO) database solution, versus 56,818/s for a direct perl hash lookup. This is a 100 fold improvement: and it's one that I can implement.
Well, we have indexes on all our key fields, and we don't do any writes.
Ok - you have indices, but are you using them? What is the execution plan for your queries? Why are you pulling all your data out instead of looking at it when you need it?
There are sooo many things involved in optimizing this kind of thing that you really need an expert on the ground, so to speak, to really give you more than just very generic places to look.
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