I know of one particular example of where typeglobs are useful, that was shown to me by ChemBoy. One of his colleagues had a variable called %SEPERATOR and ChemBoy kept "mis"-typing it because it was spelled wrong. Rather than do a global search-and-replace on the source code, which is always dangerous, he wrote: 
use vars '%SEPARATOR';
*SEPARATOR = \%SEPERATOR;

[download]
and went on his merry way using %SEPARATOR in the rest of his code.

In reply to Re: Trying to understand aliasing (*var) by Errto
in thread Trying to understand aliasing (*var) by tphyahoo

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