My suggestion is to clean it up like this:

my $dbh = DBI->connect('DBI:mysql:nikos_db', 'root', 'censored') or {R
+aiseError=>1};

my $rep = $dbh->prepare( "REPLACE INTO `games` (`gamename`, `gamedesc`
+, `gamecounter`) VALUES (?, ?, ?)" );

open (FILE, "<../data/games/descriptions.txt") or die $!;

while (<FILE>) {
  chomp;
  $rep->execute( split(/\t/, $_, 2) , 0 ) or print $dbh->errstr;
}

close (FILE);

$rep->finish;
$dbh->disconnect;
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Since the insert would fail on a duplicate, I assume you already have a primary column determined, so a replace would seem to be the best - it almost identically follows insert syntax (at least in MySQL, which, I have to admit, is the only SQL db I've ever used).

Hope this helps,