This performs a search and replace on a file as an inplace edit. The search string may be multiple lines long, but must be an exact match - including line end characters. This is not any sort of regex match!
my $matchBlock = do {local $/ = ""; <DATA>}; $/ = $matchBlock; @ARGV = ("file_to_inplace_edit.txt"); $^I = '.bak'; while (<>) { my $matched = chomp; print $_; #print everything up to the block to be replaced print "This replaces the matchBlock text\n" if $matched; } __DATA__ match string goes here. As long as you like and spanning lines if you like, but it must match exactly the text to be replaced including the line end characters in the file to be edited must be standard for the OS.
Update: Use chomp per tye's suggestion

In reply to Compact multi-line inplace file edit search and replace by GrandFather

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