split on your exceptions and grep for your matches: 
my $exceptions = qr/_ALPHA|#ALPHA|XL5 ALPHA/;
my $keepers = qr/ALPHA|BETA/;
print "Matched ($srch)!\n" if grep /$keepers/, split $exceptions, $src
+h;

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In reply to Re: Pattern matching when there are exception strings by Roy Johnson
in thread Pattern matching when there are exception strings by Moron

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