Since you want the interface to be accessible from one computer, there are a few points that I think should be mentioned.

If you use the web interface you will want to either configure the web server so that it can only accessed on the loopback device, or configure the firewall on the machine to prevent access from outside the choosen computer.

Other then that suggestion I would suggest which method would be easier for you to work with.

In reply to Re: CGI vs Tk for application backend by neosamuri
in thread CGI vs Tk for application backend by Popcorn Dave

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