Yes, USE_LARGE_FILES is enabled: 
Characteristics of this binary (from libperl):
  Compile-time options: DEBUGGING MULTIPLICITY USE_ITHREADS USE_LARGE_
+FILES PERL_IMPLICIT_CONTEXT

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In reply to Re^2: MLDBM for hash > 2GiB? by gregor-e
in thread MLDBM for hash > 2GiB? by gregor-e

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