Both sysread and <FH> will return immediately if some data (for <FH>, a whole line) were collected from the pipe. There is no need to turn on autoflush ($|) for the FH filehandle. If you are not getting the data it is because whois is probably not sending it. Probably it is using stdio, and since its output is a pipe, it is buffered. If that's the case, then there's not much you can do about it. None of the versions of whois that I have produce this status message so I cannot test whether this is so, but you can verify whether yours is outputting any data with truss or strace: 

truss -t write whois x.x.x.x 2>&1 | cat

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In reply to Re: Non-buffered read from program by Celada
in thread Non-buffered read from program by arc_of_descent

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