or use (and IMHO better because it clearly designates it as a regex to the reader) the normal //: 
  my ($one, $two) = split( /\d+\s+/, $line);

[download]
BUT.. you need the delimeter as $one .. so need to capture it: 
  my ($one, $two) = split( /(\d+\s+)/, $line);

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BUT .. that will have the space in $one .. so use a look-behind (see perlre) instead .. (and add the LIMIT) 
  my ($one, $two) = split /(?<=\d+)\s+/, $line, 2;

[download]
so to OP -- yes, it's possible w/split & regex ;)

In reply to Re^2: can split() use a regex? by davidrw
in thread can split() use a regex? by Anonymous Monk

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