The ISA Server requires authorization to fulfill the request. Access to the Web Proxy service is denied.
It may well be that the Microsoft ISA server is configured to require NTLM authentication. I've never been able to get that to work with LWP. See NTLM - Not Telling Linux Much.

In reply to Re: Need help using WWW::Mechanize to access proxy and authentication by aufflick
in thread Need help using WWW::Mechanize to access proxy and authentication by sunslinger

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