There's an official way: 
It's also possible to remove appenders from a logger:

    $logger->remove_appender($appender_name);

will remove an appender, specified by name, from a given
 logger. Please note that this does not remove an 
appender from the system.

To eradicate an appender from the system, you need to call
 Log::Log4perl->eradicate_appender($appender_name) 
which will first remove the appender from every logger 
in the system and then will delete all references 
Log4perl holds to it.

In reply to Re^2: How to turn off a Log4perl appender? by saintmike
in thread How to turn off a Log4perl appender? by mifflin

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