Ignoring the internals for now, isn't the following exactly what you're looking for? 
use strict;
use warnings;
use Log::Log4perl;

my $log_conf1 = <<EOT;
log4perl.rootLogger=DEBUG, Screen1, Screen2

log4perl.appender.Screen1=Log::Log4perl::Appender::Screen
log4perl.appender.Screen1.stderr=0
log4perl.appender.Screen1.layout=Log::Log4perl::Layout::PatternLayout
log4perl.appender.Screen1.layout.ConversionPattern = %d %-1.1p %P %H %
+m %n

log4perl.appender.Screen2=Log::Log4perl::Appender::Screen
log4perl.appender.Screen2.stderr=0
log4perl.appender.Screen2.layout=Log::Log4perl::Layout::PatternLayout
log4perl.appender.Screen2.layout.ConversionPattern = %d %-1.1p %P %H %
+m %n
EOT

Log::Log4perl->init(\$log_conf1);

Log::Log4perl->eradicate_appender("Screen1");

my $log = Log::Log4perl->get_logger;

$log->debug('this is a test');

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In reply to Re^4: How to turn off a Log4perl appender? by saintmike
in thread How to turn off a Log4perl appender? by mifflin

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