Works for me, sort of. At least it gets rid of all the newlines leaving
'AAGTAATCAAGTATTACAAGAAACAAAAATTCAAGTAAATAACAGATAATATGTCAAAAGCTGTCGGTA
+TTGATTTAGGTACAACATACTCGTGTGTTGC>YDR256CCTA
1969666970216GGGAAGAACTAAGAGATGTTATGGCTCGGAGAGTTTTGAAAAGCGAAATAGATTCGC
+TGCAAGTTTGTGAAGAAACCATCGACAAGAATTACAAGGTTAT';
What are you seeing? If you just want to compress multiple newlines, you could use
$str =~ y/\n//s;
If there are space characters on the "blank" line, you'd want something like
$str =~ s/^\s+//mg; (or
$str =~ s/^\s+\n//mg; if there may be spaces at the start of a non-blank line).
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