I suspect you should also have -D_FILE_OFFSET_BITS=64 in addition to -D_LARGEFILE_SOURCE ...
Maybe the problem is that this version had been built in a 32-bit build environment (gcc version), at least the README.hpux that comes with the Perl sources states that (emphasis added)
Using Large Files with Perl on HP-UX
... Three separate methods of doing this are available. Of these methods, the best method for Perl is to compile using the -Duselargefiles flag to Configure. This causes Perl to be compiled using structures and functions in which these are 64 bits wide, rather than 32 bits wide. (Note that this will only work with HP's ANSI C compiler. If you want to compile Perl using gcc, you will have to get a version of the compiler that supports 64-bit operations. See above for where to find it.)
Anyhow, before you go to the trouble of building your own version, you might try one the binaries generously offered for download by our very own cbu.
According to the uname signature "hp-ux waves b.11.23 u 9000800 2510705975 ..." the perl you have seems to come from the HP archive... (so there's probably no point in giving that one another try).
In reply to Re^3: File test (-e) fails on files > 2G, uselargefiles=define
by almut
in thread File test (-e) fails on files > 2G, uselargefiles=define
by perlofwisdom
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