alternatively, if it is known that the intervening line(s) will never begin with some pattern: 

my $starter = qr{    s    }xsm;  # starts with this string
my $never   = qr{    s    }xsm;  # never starts with this string
my $ender   = qr{ e [ ] p }xsm;  # ends with this string

my $start_line       = qr{ ^     $starter  [^\n]* \n }xsm;
my $intervening_line = qr{ ^ (?! $never )  [^\n]* \n }xsm;
my $end_line         = qr{                 $ender \n }xsm;

my $line = do { local $/;  <DATA> };  # slurp all the data

$line =~ s{ $start_line $intervening_line* $end_line }
          {}gxsm;

print $line;

__DATA__
Random String
s
erartt
e p
s
foo
e f
blah blah
s
adflkja
wibble wobble
e p
End of file

[download]

output: 

Random String
s
foo
e f
blah blah
End of file

[download]

In reply to Re^2: Matching and replacing the minimum string from the tail of the regex by Anonymous Monk
in thread Matching and replacing the minimum string from the tail of the regex by abitkin

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