I think you need to answer a couple of questions first:

• What do you expect to happen when you serialize the DB connection? Should the DB connection be closed? What should be stored in the serialized data structure?
• What do you expect to happen when you de-serialize the DB connection? Should the connection happen immediately? What about waiting until the first query because you may not actually use the DB connection at every given de-serialization.

There are some further concerns:

• Should passwords be stored? If so, how?
• How should DBI connections using DBD::Excel or DBD::CSV work?
• What should happen if you de-serialize the thing and attempt to use the DB connection on a box that doesn't have the right things installed?

And I'm sure that I'm missing some concerns. In other words, serializing stuff that uses external resources is non-trivial. I've run into the same problem with DBM::Deep and I don't have a really good way to solve it as of yet.

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