Well, you didn't show any code where it dosn't work. I would guess that it might be the odd way you embed your sub in the main code block, before MainLoop is called. I would write it as follows. If you can modify the code below, so it dosn't work right, please post it.

#!/usr/bin/perl
use warnings;
use strict;
use Tk;


my $mw = MainWindow->new;
$mw->Button(-text => 'Select File', -command => \&org_select )->pack;

MainLoop;

sub org_select {

   my $filetypes =     [
            ['Drawing Files',    '.drg'],
            ['All files',    '*']
            ];

   my $select_file_full = $mw->getOpenFile(
            -filetypes  => $filetypes);
}
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