You can use Regexp::Assemble to build an optimized re that matches all your typedefs: 
use Regexp::Assemble;
my $re = Regexp::Assemble->new->add(@typedefs)->re

...

if ($line =~ $re) {
  # do something
}

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In reply to Re: line by line match on an array of strings by bunch
in thread line by line match on an array of strings by barryscott

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