I ended up despairing with the SerialPort module. It's too badly documented, and threads work too slowly with Tk.

I've rewritten this as a pair of a small C++ program that bridges the serial port to/from a socket, and Perl module that uses that socket to communicate. It's available for download here (compiled for Windows, but with source code):

In reply to Re^2: Marrying Tk, threads and SerialPort - a COM port monitor by spurperl
in thread Marrying Tk, threads and SerialPort - a COM port monitor by spurperl

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