Using the sqlite database provided by CPANTS I ran a few queries. (Unreasonably) assuming I understand the schema and know how to use SQL here is the list of the top 10 modules based on number of distributions directly requiring them:
sqlite> SELECT COUNT(*) cnt, requires FROM prereq GROUP BY requires OR +DER BY cnt DESC LIMIT 10; 4324|Test::More 1181|perl 879|Carp 556|File::Spec 399|Scalar::Util 385|Test::Pod 380|LWP::UserAgent 310|DBI 292|URI 291|version
For the top 100:
4324|Test::More 1181|perl 879|Carp 556|File::Spec 399|Scalar::Util 385|Test::Pod 380|LWP::UserAgent 310|DBI 292|URI 291|version 284|Test::Exception 276|Test::Pod::Coverage 266|Test::Simple 263|Data::Dumper 248|File::Temp 242|Digest::MD5 242|POE 232|UNIVERSAL::require 228|Class::Accessor 207|Storable 205|Class::Accessor::Fast 204|Template 201|YAML 198|Catalyst 197|Module::Build 196|Time::HiRes 188|Getopt::Long 187|Exporter 181|File::Basename 177|Encode 174|DateTime 164|File::Path 164|strict 163|IO::File 153|WWW::Mechanize 152|URI::Escape 151|List::Util 151|Params::Validate 150|MIME::Base64 138|XML::Simple 131|Cwd 128|Pod::Usage 128|warnings 122|LWP 122|XML::LibXML 120|HTML::Entities 118|DBD::SQLite 116|Kwiki 115|CGI 115|File::Slurp 114|HTTP::Request 114|Log::Log4perl 113|POSIX 111|LWP::Simple 103|Class::Data::Inheritable 103|Moose 101|Class::DBI 98|File::Copy 94|Readonly 92|List::MoreUtils 92|Test::Compile 90|File::Find::Rule 83|Digest::SHA1 80|Path::Class 79|CGI::Application 79|File::Find 79|Tk 78|Params::Util 78|Parse::RecDescent 78|Test::Builder 75|FindBin 75|HTML::Parser 74|Compress::Zlib 74|DBIx::Class 71|XML::Parser 69|Fcntl 68|Error 68|Test 65|Exception::Class 65|Test::Perl::Critic 65|base 62|Catalyst::Runtime 62|IO::Scalar 62|Module::Pluggable 62|Socket 61|NEXT 61|Time::Local 60|GD 60|Test::Harness 59|Date::Parse 59|Test::Differences 58|ExtUtils::MakeMaker 58|HTML::TreeBuilder 57|Regexp::Common 56|Test::Warn 55|Class::Inspector 55|Test::MockObject 53|Filter::Simple 53|YAML::Syck 51|Clone
If we only want to include modules that are distributed on CPAN (including the dual life modules) then we have the following:
sqlite> SELECT COUNT(*) cnt, requires FROM prereq WHERE requires NOT I +N (SELECT module FROM modules WHERE dist=0) GROUP BY requires ORDER B +Y cnt DESC LIMIT 10; 4324|Test::More 556|File::Spec 399|Scalar::Util 385|Test::Pod 380|LWP::UserAgent 310|DBI 292|URI 291|version 284|Test::Exception 276|Test::Pod::Coverage
and the top 100:
4324|Test::More 556|File::Spec 399|Scalar::Util 385|Test::Pod 380|LWP::UserAgent 310|DBI 292|URI 291|version 284|Test::Exception 276|Test::Pod::Coverage 266|Test::Simple 263|Data::Dumper 248|File::Temp 242|Digest::MD5 242|POE 232|UNIVERSAL::require 228|Class::Accessor 207|Storable 205|Class::Accessor::Fast 204|Template 201|YAML 198|Catalyst 197|Module::Build 196|Time::HiRes 188|Getopt::Long 177|Encode 174|DateTime 164|File::Path 153|WWW::Mechanize 152|URI::Escape 151|List::Util 151|Params::Validate 150|MIME::Base64 138|XML::Simple 131|Cwd 128|Pod::Usage 122|LWP 122|XML::LibXML 120|HTML::Entities 118|DBD::SQLite 116|Kwiki 115|File::Slurp 114|HTTP::Request 114|Log::Log4perl 111|LWP::Simple 103|Class::Data::Inheritable 103|Moose 101|Class::DBI 94|Readonly 92|List::MoreUtils 92|Test::Compile 90|File::Find::Rule 83|Digest::SHA1 80|Path::Class 79|CGI::Application 79|Tk 78|Params::Util 78|Parse::RecDescent 78|Test::Builder 75|HTML::Parser 74|Compress::Zlib 74|DBIx::Class 71|XML::Parser 68|Error 65|Exception::Class 65|Test::Perl::Critic 62|Catalyst::Runtime 62|IO::Scalar 62|Module::Pluggable 61|Time::Local 60|GD 60|Test::Harness 59|Date::Parse 59|Test::Differences 58|ExtUtils::MakeMaker 58|HTML::TreeBuilder 57|Regexp::Common 56|Test::Warn 55|Class::Inspector 55|Test::MockObject 53|Filter::Simple 53|YAML::Syck 51|Clone 51|Math::BigInt 51|Test::Deep 50|SOAP::Lite 49|Sub::Exporter 49|Text::Balanced 48|Crypt::SSLeay 48|HTTP::Response 47|Date::Calc 47|HTTP::Request::Common 47|IO::String 46|File::HomeDir 46|Time::Piece 45|Gtk2 45|Test::Builder::Tester 44|HTML::TokeParser 44|Test::Base 43|Carp::Clan
Someone with more SQL-fu might be able to generate the list of top 10 modules when including all the other distributions that don't directly require a module.

In reply to Top prerequisites based on data from CPANTS by szabgab

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