Did you add the site in question as a 'trusted site'? Under 'Custom Level' the radio buttons with values at 'Prompt' should be descriptive enough for you to work out what you want to set to 'Disable'. It often helps to search based on the general problem you are having, especially since both modules deal with automating IE, and the problem in both questions was essentially the same.

In reply to Re^3: Win32::IE::Mechanize - Security Popups by marto
in thread Win32::IE::Mechanize - Security Popups by p6steve

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