A non-destructive s/// operator which returns the new string.
subs/methods with proper parameter lists (the usual stuff: names, Perl types, default values, basic type annotations)
Calling subs/methods with either positional or named arguments.
Declared methods, like "sub" but with implicitly declared $self.
Declared class methods, like "sub" but with implicitly declared $class.
Autoboxing which treats e.g. hashes and hashrefs in a similar way. This may remove the need to fix the ugly dereferencing syntax mess.
Many of these things seem fairly compatible with Perl 5. Some may just need a bit more support in core perl to be solid and/or fast enough to be usable.