That makes sense but I'm a little confused as how I can start/stop my thread if it's created prior to my GUI. I've attached my (hack at this) below. Thanks for any help!

use threads;
use threads::shared;
use Wx;
use Thread::Queue;
use strict;


# Maximum working threads
my $MAX_THREADS = 1;

# Flag to inform all threads that application is terminating
my $TERM :shared = 0;

# Prevents double detach attempts
my $DETACHING :shared;


package MyApp;

use base 'Wx::App';

sub OnInit {
    my $self = shift;
       
    my $frame = MyFrame->new();

    $frame->Show(1);
    $self->SetTopWindow($frame);
    return 1;
}

package MyFrame;

use base 'Wx::Frame';
use Wx qw(wxTE_MULTILINE wxVERTICAL wxID_DEFAULT);
use Wx::Event qw(EVT_COMMAND EVT_CLOSE EVT_BUTTON);

my $done_event : shared = Wx::NewEventType;

sub new {
    my $class = shift;
    my $self = $class->SUPER::new(undef, -1, "The title");

    $self->{text} = Wx::TextCtrl->new($self, -1, "", [-1,-1], [180, 10
+0], wxTE_MULTILINE);
    $self->{button_start} = Wx::Button->new($self, -1, "&Start Test");
    $self->{button_stop}  = Wx::Button->new($self, -1, "&Stop Test");
    
    my $sizer = Wx::BoxSizer->new(wxVERTICAL);
    $sizer->Add($self->{text});
    $sizer->Add($self->{button_start});
    $sizer->Add($self->{button_stop});
    $self->SetSizer($sizer);

    $self->{text}->AppendText("test\n");

    EVT_BUTTON($self,$self->{button_start}, \&DeployTestThread ); 
    EVT_BUTTON($self,$self->{button_stop}, \&StopTestThread ); 
    
    return $self;
}

sub DeployTestThread {

    # Manage the thread pool until signalled to terminate
    while (! $TERM) {

        # Keep max threads running
        for (my $needed = $MAX_THREADS - threads->list();
             $needed && ! $TERM;
             $needed--) {

            # Create New thread
            my $thread = threads->create('ExecuteTest');
        }
    }

    # Detach and kill any remaining threads
    foreach my $thr (threads->list()) {
        lock($DETACHING);
        $thr->detach() if ! $thr->is_detached();
    print "Killing " . $thr->tid() . "\n";
        $thr->kill('KILL');
    }

    print("Done\n");
}
sub StopTestThread {

    $TERM = 1;
}


sub ExecuteTest {
    my($handler, $queue) = @_;
    use LWP::Simple;
    
    # For Testing purposes
    for (1..10) {
        my @sites = qw(
            http://www.google.com/
            http://www.microsoft.com/
            http://www.yahoo.com/
            http://www.cpan.org/
            http://www.perl.org/
        );

        for(0 .. $#sites) {
            my $page = get($sites[$_]);
            my ($title1) = $page =~ /<title[^>]*>\s*(.+?)<\/title[^>]*
+>/gsi;
            my $title : shared = $title1;

            print "$title\n";

            my $thread_event = Wx::PlThreadEvent->new(-1, $done_event,
+ $title);
            Wx::PostEvent($handler, $thread_event);
        }
    }
} 

package main;
MyApp->new->MainLoop;
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