I isolating is kind of hard since I use one central code that loads functions. So it would pretty much means rewriting the entire code.
What PerlEX and Mod_Perl do is they pre-load a lot of the variables and start up into memory and then execute threads that access the persistent data.
personally I do not think im storing that much data into ram that would give it issues in spawning threads but it could be my use of namespaces :/..if there was only a way..maybe ISAPI component to monitor script start up or etc :/...or maybe some apache functions?