Yes.

• The do uses twice as much memory.
• The second uses a global variable (*FILE{IO}) without localizing it.

Cleaned up (with do ⇒ elegant):

my $raw = do {
   open(my $fh, '<', $file)
      or die("Could not read file: $!\n");
   binmode $fh;
   local $/;
   <$fh>
};
[download]

Cleaned up (without do ⇒ saves memory):

my $raw;
{
   open(my $fh, '<', $file)
      or die("Could not read file: $!\n");
   binmode $fh;
   local $/;
   $raw = <$fh>;
}
[download]

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