Here is a piece of code that will remove the signature (and only the signature!) from a message, provided the signature is stored in the __DATA__ part of the script: 

#/bin/perl -w
use strict;

# read the signatures
$/="\n\n";
my @sig= <DATA>;
chomp @sig;        # chomp every element, so we get rid of the extra \
+n

undef $/;
my $message= <>;   # read the message
 
foreach my $sig (@sig)
  { # \Q \E quotes the meta-characters in $sig
    # \s* skips trailing spaces or \n
    # and last just avoids unnecessary extra matches
    $message=~ s{\Q$sig\E\s*}{}s and last; 
  }

print $message;

__DATA__
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In reply to Re: Removing Signature from Email by mirod
in thread Removing Signature from Email by HTTP-404

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