I've done a fair amount of work with Tk under Windows in the past. When a new project came up, I decided to re-evaluate this Win32::Gui that I'd heard about.
My bout with Win32::Gui was short and painful. I found it severely under-documented -- whereas Tk has many, many pages of POD detailing every function, parameter, and copious examples -- not to mention a book on the subject -- Win32::Gui has less than minimal documentation. The examples use features which are labelled (TBD) in the docs.
Thus, I would say that the learning curve for Win32::Gui is rather steep. You'll also probably find more people out there who are aquainted with Tk than Win32::Gui. I can't really comment on speed -- but I would imagine that Win32::Gui might have a slight edge in that category. Unfortunatly, I never got to the point where that was an issue.
Hope this helps.
Update: I was unaware of the existance of the mailing list that dvergin points out below. As he says, this might make Win32::Gui a little more palatable.
perl -e 'print "I love $^X$\"$]!$/"#$&V"+@( NO CARRIER'
In reply to Re: Win32::GUI vs Tk
by Chmrr
in thread Win32::GUI vs Tk
by r.joseph
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