Gtk2 has Accessilibility features. The problem is you usually need a distro that is setup to use it, the Xserver must be setup right, etc.
Try Ubuntu and it's Accessibility setup. Google for "Ubuntu accessibility'. Once you get it setup, you can write Perl/Gtk2 GUI's that will use the accessiblity features. Ubuntu leans toward Python/Gtk2, but the Perl/Gtk2 will work fine, since Ubuntu relies on Gtk2-based Gnome.
Ubuntu is very easy to setup, and has a LiveCD capability so you can try it out without installing.
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