Is there a difference ...?

Yes, the foreach will read the entire file into memory before it starts to '# do something', while the while will process the file line by line (unless you've changed the default input record separator $/).  In the foreach case, the <FILE> is evaluated in list context, in the while case in scalar context.

In reply to Re: What’s the difference between iterating over a file with foreach or while in Perl? by almut
in thread What’s the difference between iterating over a file with foreach or while in Perl? by vinoth.ree

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