The parens spoil your match. See quotemeta. 

my $prefixSysDescr =   quotemeta 'system.sysDescr.0 : DISPLAY STRING- 
+(ascii):';
my $sysDescr       = 'system.sysDescr.0 : DISPLAY STRING- (ascii): fub
+ar';
$sysDescr          =~ s/$prefixSysDescr//;
print $sysDescr,$/;
__END__
 fubar

[download]

Alternatively, do

$sysDescr =~ s/\Q$prefixSysDescr\E//;

[download]

In reply to Re: No matching by shmem
in thread No matching by o_chfa

Title:
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