Depending on the nature of the nodes and how they're going to be accessed/manipulated, an object store (such as Pixie, Tangram, or KiokuDB) seems likely to work well for something like this, while avoiding the need to worry about SQL schemas (even if the objects are ultimately stored into an SQL database).

In reply to Re^2: Managing a graph with large number of nodes by dsheroh
in thread Managing a graph with large number of nodes by nishant2984

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