You may be able to set the appropriate registry key once, obviously this would need to be done as a user with such privilages. I'm sure if you search Google you'll find someone has done this before.

In reply to Re^3: How to change the drive letter for a CD/DVD drive on Windows? by marto
in thread How to change the drive letter for a CD/DVD drive on Windows <b>Update: with a script</b>? by matze77

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