I think the problem is that Selection is not property of Excel, rather workbook or worksheet. I tried to elaborate a bit -- this works for me: 
use Win32::OLE;
use Win32::OLE::Const 'Microsoft Excel';

my $excel = Win32::OLE->CreateObject('Excel.Application') or die $!;
$excel->{Visible} = 1;

my $workbook  = $excel->Workbooks->Add;
my $worksheet = $workbook->ActiveSheet;

$worksheet->Range('A1:B2')->{Value} = [[1,2],[2,4]];

$worksheet->Range('A1:B2')->AutoFill({
    Destination => $worksheet->Range('A1:B17'),
    Type        => xlFillDefault,
});

[download]
I am creating new workbook in example above, but you can open one as you did and access individual worksheets with Sheets property: 
my $ws2 = $workbook->Sheets('SheetName');
$ws2->...

[download]

Hope this helps

-- Roman

In reply to Re^3: Win32::OLE Excel AutoFill not working by bobr
in thread Win32::OLE Excel AutoFill not working by DaveTheMan

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