Why do you want to have the entire file in an array? In almost all cases it is far better to process your file line by line.
eg.
while (my $line = <$fh>){ if (#line matches what you're after...){ # Do action on it here... } }
When dealing with large files, it is often helpful to 'rewind' your filehandles if you are checking the last couple of lines for something and then need to go back a bit or even back to the very beginning. If thats what you're after, check out tell and seek

Update:
Since Tie::File does not load the entire file into memory, and you are still getting an out of memory error, maybe you can experiment with Tie::File's memory settings.

In reply to Re: Large text files into arrays, accessing final elements by desemondo
in thread Large text files into arrays, accessing final elements by isabella423

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