is 'NM_001005525' different from 'NM_1005525' ?
if not you have a serious bug...
if yes
90% of your keys have 6 digits putting this data into an array with 1 million entries seems reasonable... resulting in 2 MB of memory consumption if you can limit your values to 64536 numbers (it's a counter isn't it?)
the other keys have 9 digits, so it seems you are coding your genes in groups of 3 digits. All of them start with "001"
So generally - from what you show - a hash of arrays seems reasonable where the hash key represents the first 3 digits and the array the rest.
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