I don't understand the problem. Do you think somehow that a memcached client is not robust enough to handle something like that? A database server also can have problems. The clients usually handle it. memcached server and clients are really ready for production. xing uses memcached a lot. facebook uses it afaik. why do you think there could be a connection problem? did somebody tell you about problems?
I was told that if one of the memcached nodes in a cluster "vanishes" - for whatever reason - the client realizes it and reorganizes its distribution of keys then. it can't get worse than now, I'd say.