I had the same problem. I thought I had everything in 64-bit, however in my case I found that I had an environment variable set: VERSIONER_PERL_PREFER_32_BIT=yes.

Unsetting this variable made Perl run in 64-bit. Root did not use this environment variable, which explains why it worked running with sudo.

In reply to Re^4: MAC OS 10.6 upgrade breaks DBD:mysql by Anonymous Monk
in thread dyld: lazy symbol binding failed (was MAC OS 10.6 upgrade breaks DBD:mysql) by finhagen

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