Your while-loop reads line by line, so you can never match the previous line in a regex.
I gets much easier if you read the whole file into a string, and then apply a substitution.
I don't know what output you expect, but this might do you want:
s/^\s*start_of_block\s*\{.*?\};\s*//xmsg;
If not, please tell us exactly what output you want.
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