From Synopsis 03:

my $x = 'Just Another';
my $y := $x;
$y = 'Perl Hacker';
say $x;
say $y;

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The assignment operator = assigns the value of its right operand to the container which is its left operand. The binding operator := associates the container of its right operand to the name which is its left operand.

Think of it a bit like Perl 5 references without the reference or dereference operators.

In reply to Re: Perl 6, difference between ':=' and '=' by chromatic
in thread Perl 6, differrence between ':=' and '=' by Anonymous Monk

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