There is indeed lots of research showing what makes something easier to read. Then there's also recent research showing that making text more difficult to read can make the content of the text easier to remember. That's not definitive work yet and it had to do with the fonts used rather than page layout in general, but it's worth consideration.

Maybe in page layout as in Perl TIMTOWTDI. Of course, there are myriad wrong ways, too.

In reply to Re^3: Strong typing and Type Safety.A multilanguage approach by mr_mischief
in thread Strong typing and Type Safety.A multilanguage approach by nikosv

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